What do systematic reviews say?

Lamotrigine vs placebo

Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).

• Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
  RR 1.8 [1.45, 2.23]
  12 studies · 1322 participants
  Moderate