Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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Add‐on lamotrigine vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant generalised tonic‐clonic seizures

Add‐on lamotrigine may leads to higher 50% or greater reduction in seizure frequency compared with placebo (low certainty).

1 finding from 1 review

Lamotrigine add‐on therapy for drug‐resistant generalised tonic‐clonic seizures 2020 · Cochrane Headline outcomes only
RR 1.88 [1.43, 2.45]
2 studies · 270 participants
Low

Lamotrigine vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
RR 1.8 [1.45, 2.23]
12 studies · 1322 participants
Moderate