Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Anaesthesia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%

rHuEPO with iron vs control treatment with or without iron

Blood transfusion · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron probably leads to lower transfusion (measured in participants during or up to 5 days after… compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing… 2020 · Cochrane Headline outcomes only
RR 0.55 [0.38, 0.8]
12 studies · 1880 participants
Moderate

rHuEPO with iron vs control treatment with or without iron

Number of RBC units transfused per participant (intraoperative to 5 days postoperative) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

1 finding from 1 review

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing… 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1420 participants
Moderate

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing… 2020 · Cochrane Headline outcomes only
RR 1.18 [0.39, 3.63]
2 studies · 230 participants
Moderate