Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%

nHFV vs invasive respiratory therapy

Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether nHFV changes mortality before hospital discharge compared with invasive respiratory therapy (very low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.67 [0.2, 2.18]
1 study · 80 participants
Very low

nHFV vs NIPPV or NIV

Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.86 [0.9, 3.83]
2 studies · 84 participants
Low

nHFV vs HFNC

Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

nHFV vs NCPAP

Mortality before hospital discharge · ventilated preterm infants with planned extubation

nHFV showed no clear difference in mortality before hospital discharge compared with nCPAP (moderate certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.92 [0.52, 1.64]
6 studies · 1427 participants
Moderate

nHFV vs NIPPV or NIV

Mortality before hospital discharge · ventilated preterm infants with planned extubation

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.83 [0.7, 4.79]
2 studies · 984 participants
Low

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.44 [0.1, 21.33]
1 study · 39 participants
Low

nHFV vs NCPAP

Mortality before hospital discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

It is very uncertain whether nHFV changes mortality before hospital discharge compared with nCPAP used (very low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1 [0.41, 2.41]
4 studies · 531 participants
Very low