Addition of neuromuscular paralysis where previously not paralysed · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in addition of neuromuscular paralysis where previously not paralysed compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Duration of positive pressure ventilation (days) · neonates up to 44 weeks' postmenstrual age
2 findings from 1 review
Mortality before hospital discharge · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in death before discharge from hospital compared with pressure‐limited ventilation: main findings (low certainty).
1 finding from 1 review
Inspired oxygen concentration % (study definition) · neonates up to 44 weeks' postmenstrual age
1 finding from 1 review
Any pH < 7.25 · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in any pH < 7.25 compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Hypocarbia pCO2 < 35 mmHg/4.7 kPa · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower hypocarbia pCO2 < 35 mmHg/4.7 kPa compared with pressure‐limited ventilation: additional findings (moderate certainty).
1 finding from 1 review
Respiratory acidosis pH < 7.25 and pCO2 > 60 mmHg/8 kPa · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in respiratory acidosis pH < 7.25 and pCO2 > 60 mmHg/8 kPa compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Either hypocarbia or respiratory acidosis · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in either hypocarbia or respiratory acidosis compared with pressure‐limited ventilation: additional findings; GRADE not reported.
1 finding from 1 review
Patent ductus arteriosus · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in patent ductus arteriosus compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Air leak (any) · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in air leak (any) compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Pulmonary interstitial emphysema · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in pulmonary interstitial emphysema compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower death or BPD (36 weeks) compared with pressure‐limited ventilation: main findings (moderate certainty).
1 finding from 1 review
Intraventricular haemorrhage · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in any IVH compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Periventricular leukomalacia · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower PVL compared with pressure‐limited ventilation: additional findings (moderate certainty).
1 finding from 1 review
Any IVH or PVL · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in any IVH or PVL compared with pressure‐limited ventilation: additional findings (moderate certainty).
1 finding from 1 review
BPD at 28 days · neonates up to 44 weeks' postmenstrual age
Volume‐targeted showed no clear difference in BPD (supplemental oxygen at 28 days) compared with pressure‐limited ventilation: additional findings (low certainty).
1 finding from 1 review
Pneumothorax · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower pneumothorax compared with pressure‐limited ventilation: main findings (moderate certainty).
1 finding from 1 review
Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower IVH grade 3‐4 compared with pressure‐limited ventilation: main findings (moderate certainty).
1 finding from 1 review
IVH grade 3‐4 or PVL · neonates up to 44 weeks' postmenstrual age
Volume‐targeted probably leads to lower IVH grade 3‐4 or PVL compared with pressure‐limited ventilation: main findings (moderate certainty).
1 finding from 1 review
Oxygen requirement at 36 weeks' postmenstrual age · neonates up to 44 weeks' postmenstrual age
Volume‐targeted may leads to lower BPD (supplemental oxygen at 36 weeks) compared with pressure‐limited ventilation: main findings (low certainty).
1 finding from 1 review