Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

780 questions · 834 findings · 76 reviews

No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin D vs placebo or control

Lumbar spine bone mineral density (BMD) · children

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in lumbar spine, Healthy children: SMD 0.15 (95% CI -0.01 to 0.31), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Hip Fracture · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: hip, Men aged >65 years and postmenopausal women: RR 1.15 (95% CI 0.99 to 1.33), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Systolic blood pressure · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for Systolic blood pressure: WMD -2.39 (95% CI -5.7 to 0.9), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Vitamin D vs placebo or control

Bone mineral density · children

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density (Whole body / total), Healthy children: SMD 0.1 (95% CI -0.06 to 0.26), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Vitamin D vs placebo or control

Hip/femoral bone mineral density (BMD) · children

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in hip, Healthy children: SMD 0.06 (95% CI -0.18 to 0.29), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Vitamin D vs placebo or control

Bone mineral density · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density, Community-dwelling adults: WMD -0.9 (95% CI -2.10 to 0.40), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Insulin resistance · Adults with diabetes

Meta-analysis of randomised trials of vitamin D supplementation for Insulin resistance (Diabetes): SMD 0.16 (95% CI -0.11 to 0.42), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Multivitamin vs placebo

Average mouth pain during RAS episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in average mouth pain during RAS episodes compared with placebo; GRADE not reported.

1 finding from 1 review