Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

780 questions · 834 findings · 76 reviews

No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

3 findings from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound width reduction · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

LongoVital (herbal plus vitamin component) vs LongoVital (herbal component alone)

Number of ulcer-free days and number of new ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • A single trial at high risk of bias (Kolseth 2005) randomised participants to the herbal component of LongoVital alone or LongoVital with herbal plus vitamin component. Data presented as medians with 95% CIs,…
    1 study · 40 participants
    GRADE not reported

LongoVital (herbal plus vitamin component) vs LongoVital (herbal component alone)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

LongoVital (herbal plus vitamin component) vs placebo

Number of ulcer-free days and number of new ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Forty patients were randomised to receive LongoVital (herbal plus vitamin) or placebo (Kolseth 2005). Data presented as medians with 95% confidence intervals, unsuitable for further analysis. The authors report no…
    1 study · 40 participants
    GRADE not reported