What do systematic reviews say?

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

• Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  Very low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

• Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 944 participants
  Very low

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

• Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

The review found no eligible studies for this question.

• Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

• Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

The review found no eligible studies for this question.

• Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low‐level laser therapy, wrist splint, and vitamin B6 vs placebo, wrist splint, and vitamin B6

The review found no eligible studies for this question.

• Low‐level laser therapy for carpal tunnel syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement probably leads to lower progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo or no treatment (moderate certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.72 [0.58, 0.9]
  3 studies · 2445 participants
  Moderate

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement probably leads to lower progression to neovascular AMD compared with placebo or no treatment (moderate certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.62 [0.47, 0.82]
  1 study · 1206 participants
  Moderate

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement showed no clear difference in progression to geographic atrophy compared with placebo or no treatment (moderate certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.75 [0.51, 1.1]
  1 study · 1206 participants
  Moderate

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement probably leads to lower progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo or no treatment (moderate certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.77 [0.62, 0.96]
  1 study · 1791 participants
  Moderate

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 110 participants
  Low

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Antioxidant multivitamin and mineral supplement may leads to lower adverse effects compared with placebo or no treatment (low certainty).

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  OR 0.87
  0 participants
  Low

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

The review found no eligible studies for this question.

• Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.82 [0.55, 1.22]
  8 studies · 1898 participants
  Low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.56 [0.37, 0.84]
  11 studies · 1777 participants
  Very low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1240 participants
  Very low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0 [0, 0]
  0 studies · 0 participants
  GRADE not reported

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in birthweight (g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  MD 5.13
  9 studies · 1939 participants
  Low

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in premature birth (less than 37 weeks of gestation) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

• Intermittent oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 1.03 [0.76, 1.39]
  5 studies · 1177 participants
  Low