Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

780 questions · 834 findings · 76 reviews

No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Pulmonary embolism · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

It is very uncertain whether vitamin K antagonist (VKA) prophylaxis changes pulmonary embolism compared with no prophylaxis (very low certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Symptomatic DVT · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

It is very uncertain whether vitamin K antagonist (VKA) prophylaxis changes symptomatic deep vein thrombosis compared with no prophylaxis (very low certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Major bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis probably leads to higher major bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis probably leads to higher minor bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Fondaparinux plus vitamin K antagonist vs usual care

Major bleeding · people > 18 years of age with a diagnosed deep vein thrombosis

Fondaparinux plus vitamin K antagonist showed no clear difference in major bleeding during the initial treatment compared with standard therapy (moderate certainty).

2 findings from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

3 findings from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound width reduction · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

LongoVital (herbal plus vitamin component) vs placebo

Number of ulcer-free days and number of new ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Forty patients were randomised to receive LongoVital (herbal plus vitamin) or placebo (Kolseth 2005). Data presented as medians with 95% confidence intervals, unsuitable for further analysis. The authors report no…
    1 study · 40 participants
    GRADE not reported