Frequency of pain crises in the · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of pain crisis compared with placebo (very low certainty).
1 finding from 1 review
Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).
1 finding from 1 review
QoL of participants living with SCD and their caregivers · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
Frequency of hospitalization · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).
1 finding from 1 review
Haemoglobin status · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
1 finding from 1 review
Incidence: lung cancer · healthy people and healthy male physicians
Vitamin A showed no clear difference in incidence: lung cancer compared with placebo (high certainty).
1 finding from 1 review
Mortality: lung cancer · healthy people and healthy male physicians
Vitamin A showed no clear difference in mortality: lung cancer compared with placebo (high certainty).
1 finding from 1 review
Incidence: lung cancer · healthy people
Vitamin E showed no clear difference in incidence: lung cancer compared with placebo (high certainty).
1 finding from 1 review
Mortality: lung cancer · healthy people
Vitamin E showed no clear difference in mortality: lung cancer compared with placebo (high certainty).
1 finding from 1 review
Adverse events: haemorrhagic stroke · healthy people
Vitamin E leads to higher adverse events: haemorrhagic stroke compared with placebo (high certainty).
1 finding from 1 review
Incidence: all cancers · healthy people
Vitamin E showed no clear difference in incidence: all cancers compared with placebo (high certainty).
1 finding from 1 review
Mortality: all cancers · healthy people
Vitamin E showed no clear difference in mortality: all cancers compared with placebo (high certainty).
1 finding from 1 review
Mortality: all causes · healthy people
Vitamin E showed no clear difference in mortality: all causes compared with placebo (high certainty).
1 finding from 1 review
Adverse events: yellowing of the skin · healthy people and healthy male physicians
Vitamin A leads to higher adverse events: yellowing of the skin compared with placebo (high certainty).
1 finding from 1 review
Adverse events: minor gastrointestinal symptoms · healthy people and healthy male physicians
Vitamin A leads to higher adverse events: minor gastrointestinal symptoms compared with placebo (high certainty).
1 finding from 1 review
Incidence: all cancers · healthy people and healthy male physicians
Vitamin A showed no clear difference in incidence: all cancers compared with placebo (high certainty).
1 finding from 1 review
Mortality: all cancers · healthy people and healthy male physicians
Vitamin A showed no clear difference in mortality: all cancers compared with placebo (high certainty).
1 finding from 1 review
Mortality: all causes ‐ smokers and asbestos workers · healthy people and healthy male physicians
Vitamin A leads to higher mortality: all causes ‐ smokers and asbestos workers compared with placebo (high certainty).
1 finding from 1 review