Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Varenicline vs placebo or no medication

SAEs · people who smoke

Varenicline probably leads to higher SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (moderate certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.23 [1.01, 1.48]
26 studies · 14356 participants
Moderate

Varenicline vs placebo or no medication

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.2 [0.79, 1.84]
18 studies · 7151 participants
Low

Varenicline vs placebo or no medication

Neuropsychiatric SAEs · people who smoke

Varenicline showed no clear difference in neuropsychiatric SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.89 [0.61, 1.29]
22 studies · 7846 participants
Low