Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 0 · 0%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

SAEs · people who smoke

Varenicline may leads to lower SAEs compared with nicotine replacement therapy monotherapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.7 [0.5, 0.99]
6 studies · 6535 participants
Low

SAEs · people who smoke

Varenicline showed no clear difference in SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 2.15 [0.49, 9.46]
4 studies · 1852 participants
Low

Cardiac SAEs · people who smoke

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
GRADE not reported

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.88]
2 studies · 819 participants
Low

Neuropsychiatric SAEs · people who smoke

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
GRADE not reported

Neuropsychiatric SAEs · people who smoke

Varenicline showed no clear difference in neuropsychiatric SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.69 [0.23, 96.5]
2 studies · 764 participants
Low