Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

SAEs · people who smoke

Varenicline showed no clear difference in SAEs compared with bupropion (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.89 [0.61, 1.31]
5 studies · 5317 participants
Low

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs compared with bupropion (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 3.17 [0.33, 30.18]
2 studies · 866 participants
Low

Neuropsychiatric SAEs · people who smoke

Varenicline showed no clear difference in neuropsychiatric SAEs compared with bupropion (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.05 [0.16, 7.04]
2 studies · 866 participants
Low