Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 2 · 40%Very low 0 · 0%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

Varenicline vs nicotine replacement therapy monotherapy

Cardiac SAEs · people who smoke

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
GRADE not reported

Varenicline vs combination nicotine replacement therapy

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.88]
2 studies · 819 participants
Low

Varenicline vs bupropion

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs compared with bupropion (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 3.17 [0.33, 30.18]
2 studies · 866 participants
Low

Varenicline vs e‐cigarettes

Cardiac SAEs · people who continued to smoke tobacco following acute coronary syndrome

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 54 participants
GRADE not reported

Varenicline vs placebo or no medication

Cardiac SAEs · people who smoke

Varenicline showed no clear difference in cardiac SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (low certainty).

1 finding from 1 review

Nicotine receptor partial agonists for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.2 [0.79, 1.84]
18 studies · 7151 participants
Low