Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews · Headline outcomes only

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No studies found 1 · 7.1%GRADE not reported 0 · 0%Very low 2 · 14.3%Low 11 · 78.6%Moderate 0 · 0%High 0 · 0%

Vaginal misoprostol vs surgical evacuation of uterus

Blood loss: post‐treatment haematocrit (%) · early fetal death (less than 24 weeks)

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Vaginal misoprostol vs placebo

Complete miscarriage · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher complete miscarriage compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 4.23 [3.01, 5.94]
5 studies · 305 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher nausea compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 21.85 [1.31, 364.37]
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Diarrhoea · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher diarrhoea compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 40.85 [2.52, 662.57]
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher pain relief compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.42
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Woman’s satisfaction/acceptability of method · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.67 [0.4, 1.11]
1 study · 45 participants
Low

Vaginal misoprostol vs placebo

Pelvic infection · early fetal death (less than 24 weeks)

The review found no eligible studies for this question.

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vaginal misoprostol vs placebo

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in nausea compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.38 [0.43, 4.4]
2 studies · 88 participants
Low

Vaginal misoprostol vs placebo

Diarrhoea · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in diarrhoea compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 2.21 [0.35, 14.06]
2 studies · 88 participants
Low

Vaginal misoprostol vs placebo

Blood loss: haemoglobin difference > 10 g/L · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes blood loss: haemoglobin difference > 10 g/L compared with placebo (very low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.25 [0.38, 4.12]
1 study · 50 participants
Very low

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 5 [0.25, 101.11]
1 study · 84 participants
Very low

Vaginal misoprostol vs placebo

Woman’s satisfaction/acceptability of method · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.17 [0.83, 1.64]
1 study · 32 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Complete miscarriage · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to lower complete miscarriage compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.4 [0.32, 0.5]
6 studies · 943 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Pelvic infection · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in pelvic infection compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.73 [0.39, 1.37]
1 study · 618 participants
Low