Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 18 findings · 1 reviews · Incontinence

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 13 · 72.2%Low 5 · 27.8%Moderate 0 · 0%High 0 · 0%

Tricyclic antidepressants vs Other Drug for

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with another drug (very low certainty).

2 findings from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (very low certainty).

2 findings from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy (reassurance, retention control training + wakening, parental involvement) · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy + motivation/counselling + education · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights or relapsing at · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights or relapsing at compared with behavioural interventions (very low certainty).

2 findings from 1 review

Tricyclic antidepressants vs placebo

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with placebo (very low certainty).

2 findings from 1 review