Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 4 · 80%Moderate 0 · 0%High 0 · 0%

Tricyclic antidepressants vs placebo

Efficacy for ADHD symptoms (parents using a rating scale) ‐ desipramine · Children and adolescents with ADHD

1 finding from 1 review

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 99 participants
Low

Tricyclic antidepressants vs placebo

Efficacy for ADHD symptoms (teachers using a rating scale) ‐ desipramine · Children and adolescents with ADHD

1 finding from 1 review

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Low

Tricyclic antidepressants vs placebo

CGI (response rate) ‐ desipramine and nortriptyline · Children and adolescents with ADHD

Tricyclic antidepressants (TCAs) may leads to higher CGI (response rate) ‐ desipramine and nortriptyline compared with placebo (low certainty).

1 finding from 1 review

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
OR 18.5 [6.29, 54.39]
3 studies · 125 participants
Low

Tricyclic antidepressants vs placebo

Clinical global impression (response rate) ‐ desipramine · Children and adolescents with ADHD

Tricyclic antidepressants (TCAs) may leads to higher clinical global impression (response rate) ‐ desipramine compared with placebo (low certainty).

1 finding from 1 review

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
OR 26.41 [7.41, 94.18]
2 studies · 103 participants
Low

Tricyclic antidepressants vs placebo

All‐cause treatment discontinuation ‐ desipramine · Children and adolescents with ADHD

1 finding from 1 review

Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 134 participants
Very low