What do systematic reviews say?

Tricyclic antidepressants vs placebo

Tricyclic antidepressants (TCAs) may leads to higher clinical global impression (response rate) ‐ desipramine compared with placebo (low certainty).

• Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents 2014 · Cochrane Headline outcomes only
  OR 26.41 [7.41, 94.18]
  2 studies · 103 participants
  Low