Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

49 questions · 49 findings · 5 reviews

No studies found 25 · 51%GRADE not reported 0 · 0%Very low 22 · 44.9%Low 2 · 4.1%Moderate 0 · 0%High 0 · 0%

Recombinant human adenovirus‐p53 and 5‐fluorouracil (rAd‐p53/5‐Fu) plus transarterial chemoembolisation vs chemoembolisation

Disease progression · participants with unresectable hepatocellular carcinoma

It is very uncertain whether recombinant human adenovirus‐p53 and 5‐fluorouracil (rAd‐p53/5‐Fu)… changes proportion of people with disease progression compared with transarterial chemoembolisation (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Complete response plus partial response Length of · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to higher complete response plus partial response Length of compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated alanine aminotransferase Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated alanine aminotransferase Length of compared with TACE alone (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated total bilirubin Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated total bilirubin Length of compared with TACE alone (very low certainty).

1 finding from 1 review