What do systematic reviews say?

Total thyroidectomy vs subtotal thyroidectomy

Total thyroidectomy probably leads to lower rate of recurrent hyperthyroidism [measured by thyroid function tests] compared with subtotal thyroidectomy (moderate certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 0.14 [0.04, 0.46]
  2 studies · 350 participants
  Moderate
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 0.13 [0.04, 0.44]
  2 studies · 300 participants
  Moderate

Total thyroidectomy vs subtotal thyroidectomy

Total thyroidectomy showed no clear difference in permanent recurrent laryngeal nerve palsy [patient reported,… compared with bilateral subtotal thyroidectomy (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1 [0.14, 7.15]
  2 studies · 300 participants
  Low
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.45 [0.38, 5.59]
  3 studies · 393 participants
  Low

Total thyroidectomy vs subtotal thyroidectomy

Total thyroidectomy showed no clear difference in permanent hypocalcaemia/hypoparathyroidism [measured by serum… compared with bilateral subtotal thyroidectomy (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 2.04 [0.53, 7.85]
  2 studies · 300 participants
  Low
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 4.79 [1.36, 16.83]
  3 studies · 393 participants
  Low

Total thyroidectomy vs subtotal thyroidectomy

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 300 participants
  GRADE not reported
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 350 participants
  GRADE not reported

Total thyroidectomy vs subtotal thyroidectomy

The review found no eligible studies for this question.

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Total thyroidectomy vs subtotal thyroidectomy

The review found no eligible studies for this question.

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Total thyroidectomy vs subtotal thyroidectomy

Total thyroidectomy showed no clear difference in regression of Graves' ophthalmopathy [ophthalmology assessment] compared with subtotal thyroidectomy (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.15 [0.64, 2.08]
  2 studies · 229 participants
  Low
• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.19 [0.64, 2.21]
  2 studies · 260 participants
  Low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Bilateral subtotal thyroidectomy may leads to higher R ate of recurrent hyperthyroidism [measured by thyroid function… compared with the Dunhill procedure (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 2.73 [1.28, 5.85]
  3 studies · 592 participants
  Low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Bilateral subtotal thyroidectomy showed no clear difference in regression of Graves' ophthalmopathy [ophthalmology assessment] compared with the Dunhill procedure (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 0.78 [0.32, 1.92]
  2 studies · 90 participants
  Low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Bilateral subtotal thyroidectomy showed no clear difference in permanent recurrent laryngeal nerve palsy [patient reported,… compared with the Dunhill procedure (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 0.14 [0, 6.82]
  3 studies · 592 participants
  Low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

Bilateral subtotal thyroidectomy showed no clear difference in permanent hypocalcaemia/hypoparathyroidism [measured by serum… compared with the Dunhill procedure (low certainty).

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  OR 1.9 [0.47, 7.71]
  3 studies · 592 participants
  Low

Bilateral subtotal thyroidectomy vs the Dunhill procedure

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 642 participants
  GRADE not reported

Bilateral subtotal thyroidectomy vs the Dunhill procedure

The review found no eligible studies for this question.

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Bilateral subtotal thyroidectomy vs the Dunhill procedure

The review found no eligible studies for this question.

• Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found