Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Epilepsy

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No studies found 2 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Topiramate plus ASMs vs placebo plus ASMs

Seizure freedom · Lennox‐Gastaut syndrome, any age

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐seizure medications for Lennox‐Gastaut syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topiramate plus ASMs vs placebo plus ASMs

Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age

Topiramate plus ASMs showed no clear difference in number of participants with ≥ 75% reduction in all seizures compared with placebo plus ASMs (low certainty).

1 finding from 1 review

Anti‐seizure medications for Lennox‐Gastaut syndrome 2021 · Cochrane Headline outcomes only
Peto OR 8.22 [0.6, 112.62]
1 study · 98 participants
Low

Topiramate plus ASMs vs placebo plus ASMs

50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐seizure medications for Lennox‐Gastaut syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topiramate plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

1 finding from 1 review

Anti‐seizure medications for Lennox‐Gastaut syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 98 participants
Low