Findings

What do systematic reviews say?

6 questions · 7 findings · 1 reviews

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No studies found 5 · 71.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 0 · 0%High 1 · 14.3%

Topiramate as monotherapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).

1 finding from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
OR 0.87 [0.5, 1.52]
1 study · 230 participants
Low

Topiramate as monotherapy vs alternative drug

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topiramate as monotherapy vs alternative drug

> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topiramate as monotherapy vs alternative drug

Remission · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

2 findings from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topiramate as monotherapy vs alternative drug

Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder

1 finding from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 449 participants
High

Topiramate as monotherapy vs alternative drug

Change in depressive symptoms · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate for acute affective episodes in bipolar disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found