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Evidence found and GRADE certainty

25 questions · 29 findings · 1 reviews · Common Mental Disorders

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No studies found 18 · 62.1%GRADE not reported 0 · 0%Very low 3 · 10.3%Low 6 · 20.7%Moderate 1 · 3.4%High 1 · 3.4%

Topiramate vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Topiramate vs placebo

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate vs placebo

Remission · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

2 findings from 1 review

Topiramate vs placebo

Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
2 findings from 1 review

Topiramate as monotherapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).

1 finding from 1 review

Topiramate as monotherapy vs alternative drug

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate as monotherapy vs alternative drug

Remission · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

2 findings from 1 review

Topiramate as add‐on therapy vs placebo

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

Topiramate as add‐on therapy showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs placebo

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

Topiramate as add‐on therapy showed no clear difference in response to treatment with topiramate. Number of participants… compared with placebo (low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs placebo

Remission · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

2 findings from 1 review

Topiramate as add‐on therapy vs alternative drug

Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes acceptability with topiramate (8 weeks) Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes response to treatment with topiramate. Number of participants… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate as add‐on therapy vs alternative drug

Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes (8 weeks) · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes remission with topiramate. Number of participants presenting with a… compared with alternative drug (very low certainty).

1 finding from 1 review