Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 57.1%High 3 · 42.9%

Tiotropium vs ipratropium

Change in baseline trough FEV1 · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1073 participants
Moderate

Tiotropium vs ipratropium

All‐cause serious adverse events · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium leads to lower all‐cause serious adverse events compared with ipratropium (high certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 0.5 [0.34, 0.73]
2 studies · 1073 participants
High

Tiotropium vs ipratropium

Hospital admissions · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium probably leads to lower hospital admissions (all‐cause) compared with ipratropium (moderate certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 0.34 [0.15, 0.76]
1 study · 538 participants
Moderate

Tiotropium vs ipratropium

Mortality (all‐cause) · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium showed no clear difference in mortality (all‐cause) compared with ipratropium (moderate certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 1.39 [0.44, 4.39]
2 studies · 1073 participants
Moderate

Tiotropium vs ipratropium

Quality of life ( · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 535 participants
Moderate

Tiotropium vs ipratropium

Exacerbations · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium leads to lower patients with one or more exacerbations compared with ipratropium (high certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 0.71 [0.52, 0.95]
2 studies · 1073 participants
High

Tiotropium vs ipratropium

Treatment withdrawal · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium leads to lower withdrawals compared with ipratropium (high certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 0.58 [0.41, 0.83]
2 studies · 1073 participants
High