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Evidence found and GRADE certainty

7 questions · 7 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 0 · 0%Low 1 · 14.3%Moderate 2 · 28.6%High 3 · 42.9%

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Quality of life SGRQ responder analysis at 6 months · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium probably leads to higher quality of life SGRQ responder analysis at 6 months compared with tiotropium alone (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonist plus tiotropium vs long‐acting beta2‐agonist alone

Quality of life SGRQ responder analysis at 6 months · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium probably leads to higher quality of life SGRQ responder analysis at 6 months compared with long‐acting beta2‐agonist alone (moderate certainty).

1 finding from 1 review

Tiotropium vs placebo

Number of patients with a clinically significant worsening (≥ 4 units) in quality of life (SGRQ) · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to lower number of patients with a clinically significant worsening (≥ 4… compared with placebo (high certainty).

1 finding from 1 review

Tiotropium vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to higher number of patients with a clinically significant improvement (≥ 4… compared with placebo (high certainty).

1 finding from 1 review