Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Haematology

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 1 · 12.5%Very low 3 · 37.5%Low 3 · 37.5%Moderate 1 · 12.5%High 0 · 0%

Thrombopoietin mimetics vs placebo

Number of participants with at least 1 bleeding episode · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one bleeding episode compared with placebo (low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.31]
4 studies · 206 participants
Low

Thrombopoietin mimetics vs placebo

Number of participants with severe or life‐threatening bleeding · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one severe or life‐threatening… compared with placebo (low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 0.31 [0.04, 2.26]
1 study · 40 participants
Low

Thrombopoietin mimetics vs placebo

All‐cause mortality · People with chronic bone marrow failure

It is very uncertain whether thrombopoietin mimetic changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 0.74 [0.52, 1.05]
5 studies · 456 participants
Very low

Thrombopoietin mimetics vs placebo

Proportion of patients receiving platelets · People with chronic bone marrow failure

Thrombopoietin mimetic probably leads to lower proportion of participants receiving a platelet transfusion compared with placebo (moderate certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 0.76 [0.61, 0.95]
4 studies · 206 participants
Moderate

Thrombopoietin mimetics vs placebo

Blood transfusion reaction · People with chronic bone marrow failure

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
0.06 [0, 3.44]
1 study · 98 participants
Very low

Thrombopoietin mimetics vs placebo

Thromboembolism · People with chronic bone marrow failure

It is very uncertain whether thrombopoietin mimetic changes thromboembolism compared with placebo (very low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 1.41 [0.39, 5.01]
5 studies · 456 participants
Very low

Thrombopoietin mimetics vs placebo

Adverse drug reactions · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in drug reactions compared with placebo (low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 1.12 [0.83, 1.51]
5 studies · 455 participants
Low

Thrombopoietin mimetics vs placebo

Number of red cell transfusions per participant · People with chronic bone marrow failure

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 98 participants
GRADE not reported