What do systematic reviews say?

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in mortality Mortality at latest compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 1.06 [0.75, 1.49]
  3 studies · 413 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in acute rejection The number of patients who experienced at least one… compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 0.89 [0.77, 1.05]
  2 studies · 323 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus probably leads to lower bronchiolitis obliterans syndrome The number of patients diagnosed… compared with cyclosporin (moderate certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 0.46 [0.29, 0.74]
  3 studies · 413 participants
  Moderate

Tacrolimus vs cyclosporin

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus may leads to lower treatment withdrawal the number of patients stopping the assigned… compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 0.27 [0.16, 0.46]
  3 studies · 413 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus may leads to lower arterial hypertension compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 0.67 [0.5, 0.89]
  2 studies · 164 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus may leads to higher diabetes mellitus compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 4.24 [1.58, 11.4]
  2 studies · 164 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in treatment response at 6 months: complete remission compared with cyclosporin (low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 1.14 [0.64, 2.03]
  1 study · 41 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in treatment response at 6 months: complete and partial remission compared with cyclosporin (low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 0.57 [0.16, 2.08]
  1 study · 41 participants
  Low
• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 1.05 [0.87, 1.25]
  2 studies · 58 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in treatment response at 12 months: complete remission compared with cyclosporin (low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 0.8 [0.45, 1.42]
  2 studies · 58 participants
  Low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in adverse events: persistent nephrotoxicity compared with cyclosporin (low certainty).

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  RR 0.48 [0.05, 4.85]
  1 study · 41 participants
  Low

Tacrolimus vs cyclosporin

• Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 58 participants
  Low