What do systematic reviews say?

INTENSIVE CASE MANAGEMENT vs usual care

The review found no eligible studies for this question.

• Intensive case management for severe mental illness 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

INTENSIVE CASE MANAGEMENT vs usual care

Intensive Case Management may leads to lower global state: 1. Leaving the study early ‐ by long term compared with standard care (low certainty).

• Intensive case management for severe mental illness 2017 · Cochrane Headline outcomes only
  RR 0.68 [0.58, 0.79]
  13 studies · 1798 participants
  Low

INTENSIVE CASE MANAGEMENT vs usual care

It is very uncertain whether intensive Case Management changes social functioning: 2. Employment status (various measurements) ‐ by… compared with standard care (very low certainty).

• Intensive case management for severe mental illness 2017 · Cochrane Headline outcomes only
  RR 0.7 [0.49, 1]
  4 studies · 1129 participants
  Very low

INTENSIVE CASE MANAGEMENT vs usual care

The review found no eligible studies for this question.

• Intensive case management for severe mental illness 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensive glycaemic control vs conventional glucose control

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intensive glycaemic control vs conventional glucose control

The review found no eligible studies for this question.

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensive glycaemic control vs conventional glucose control

Intensive glucose control may leads to higher severe hypoglycaemia, baseline HbA1c < 9.0 compared with conventional glucose control (low certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 1.68 [1.29, 2.19]
  3 studies · 1583 participants
  Low

Intensive glycaemic control vs conventional glucose control

Intensive glucose control showed no clear difference in severe hypoglycaemia, baseline HbA1c ≥9.0 compared with conventional glucose control (low certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.66, 1.64]
  8 studies · 525 participants
  Low

Intensive glycaemic control vs conventional glucose control

It is very uncertain whether intensive glucose control changes ketoacidosis compared with conventional glucose control (very low certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  OR 4.93 [1.18, 20.6]
  3 studies · 96 participants
  Very low

Intensive glycaemic control vs conventional glucose control

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1441 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

Intensive glucose control showed no clear difference in all‐cause mortality compared with conventional glucose control (moderate certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  OR 1.02 [0.48, 2.19]
  10 studies · 2039 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1441 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

The review found no eligible studies for this question.

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensive glycaemic control vs conventional glucose control

Intensive glucose control leads to lower manifestation of retinopathy compared with conventional glucose control (high certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 0.27 [0.18, 0.42]
  2 studies · 768 participants
  High

Intensive glycaemic control vs conventional glucose control

Intensive glucose control probably leads to lower progression of retinopathy compared with conventional glucose control (moderate certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 0.61 [0.49, 0.76]
  2 studies · 764 participants
  Moderate
• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 2.32 [1.16, 4.63]
  2 studies · 96 participants
  Low

Intensive glycaemic control vs conventional glucose control

Intensive glucose control probably leads to lower manifestation of nephropathy compared with conventional glucose control (moderate certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 0.56 [0.46, 0.68]
  3 studies · 1475 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

It is very uncertain whether intensive glucose control changes progression of nephropathy compared with conventional glucose control (very low certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 0.79
  3 studies · 179 participants
  Very low

Intensive glycaemic control vs conventional glucose control

Intensive glucose control leads to lower manifestation of neuropathy compared with conventional glucose control (high certainty).

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  RR 0.35 [0.23, 0.53]
  3 studies · 1203 participants
  High

Intensive glycaemic control vs conventional glucose control

The review found no eligible studies for this question.

• Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Intensification of prophylactic therapy guided by colonoscopy showed no clear difference in clinical recurrence ( compared with intensification guided by clinical recurrence (low certainty).

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  RR 0.82 [0.56, 1.18]
  1 study · 174 participants
  Low