Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews

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No studies found 3 · 50%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 0 · 0%Moderate 0 · 0%High 1 · 16.7%

Antihypertensive drug therapy vs placebo or no treatment

Total serious adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension‐induced left ventricular hypertrophy 2021 · Cochrane Headline outcomes only
RR 1.02 [0.89, 1.16]
3 studies · 930 participants
Very low

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

Serious adverse events · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Serious adverse events · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs placebo

Serious adverse events · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Induced hypertension vs placebo or no intervention

Proportion of participants with ≥ 1 serious adverse events · people with acute subarachnoid haemorrhage

It is very uncertain whether induced hypertension changes proportion of participants with ≥ 1 serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Interventions for altering blood pressure in people with acute subarachnoid haemorrhage 2021 · Cochrane Headline outcomes only
RR 2.24 [1.01, 4.99]
2 studies · 61 participants
Very low

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
RR 6.27 [4.15, 9.49]
2 studies · 2748 participants
High