Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

HIV infection · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF+ FTC probably leads to lower HIV infection compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 0.49 [0.28, 0.85]
4 studies · 8813 participants
Moderate

Serious adverse events · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF+ FTC showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 1 [0.83, 1.19]
3 studies · 6862 participants
Moderate