Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCA showed no clear difference in failure to respond compared with MAOI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.59 [0.28, 1.26]
1 study · 135 participants
Low

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCAs showed no clear difference in failure to respond compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.08 [0.71, 1.66]
4 studies · 438 participants
Low

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

It is very uncertain whether TCAs changes failure to respond compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.02 [0.63, 1.67]
1 study · 61 participants
Very low