Systemic TXA probably leads to lower blood transfusion compared with no TXA (placebo or usual care) (moderate certainty).
Systemic TXA showed no clear difference in stone‐free rate compared with no TXA (placebo or usual care) (low certainty).
Systemic TXA showed no clear difference in adverse events compared with no TXA (placebo or usual care) (low certainty).
Systemic TXA showed no clear difference in secondary interventions compared with no TXA (placebo or usual care) (low certainty).
Systemic TXA probably leads to lower major surgical complications compared with no TXA (placebo or usual care) (moderate certainty).
Systemic TXA showed no clear difference in minor surgical complications compared with no TXA (placebo or usual care) (low certainty).
It is very uncertain whether systemic TXA changes unplanned hospitalizations or readmissions compared with no TXA (placebo or usual care) (very low certainty).