Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes surgery for recurrent or persistent disease compared with preoperative pharmacological therapy and surgery (very low certainty).
1 finding from 1 review
Disease‐related complications Intubation difficulties requiring postponement of surgery · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes disease‐related complications Intubation difficulties requiring… compared with preoperative pharmacological therapy and surgery (very low certainty).
1 finding from 1 review
1‐Year radiosurgery‐targeted lesion controlNo. of participants: 602(4 RCTs) · patients with newly diagnosed multiple brain metastases
Radiosurgery alone leads to higher 1‐Year radiosurgery‐targeted lesion controlNo. of participants:… compared with WBRT and radiosurgery (high certainty).
1 finding from 1 review
HR 2.73 [1.87, 3.99]
Studies not reported
High
Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes adverse events compared with preoperative pharmacological therapy and surgery (very low certainty).
1 finding from 1 review
All‐cause mortality · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Non‐surgical therapy for recurrent or persistent diseaseRadiation therapy and/or pharmacologic therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes non‐surgical therapy for recurrent or persistent diseaseRadiation… compared with preoperative pharmacological therapy and surgery (very low certainty).
1 finding from 1 review
Health‐related quality of life · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrence · adults with growth‐hormone secreting pituitary adenomas
1 finding from 1 review
Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases
Radiosurgery alone showed no clear difference in overall survivalNo. of participants: 403(3 RCTs) compared with WBRT and radiosurgery (moderate certainty).
1 finding from 1 review
HR 1 [0.8, 1.25]
Studies not reported
Moderate
1‐Year distant brain controlNo. of participants: 602(4 RCTs) · patients with newly diagnosed multiple brain metastases
Radiosurgery alone leads to higher 1‐Year distant brain controlNo. of participants: 602(4 RCTs) compared with WBRT and radiosurgery (high certainty).
1 finding from 1 review
HR 2.34 [1.73, 3.18]
Studies not reported
High
Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases
1 finding from 1 review
no estimate extracted
Studies not reported
High
NeurocognitionNo. of participants: 403(3 RCTs) · patients with newly diagnosed multiple brain metastases
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Neurological functionNo. of participants: 544(3 RCTs) · patients with newly diagnosed multiple brain metastases
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Quality of lifeNo. of participants: 271(2 RCTs) · patients with newly diagnosed multiple brain metastases
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Disease‐related complications · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrence · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes adverse events compared with pharmacological therapy alone (very low certainty).
1 finding from 1 review
All‐cause mortality · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Non‐surgical therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found