Findings

What do systematic reviews say?

28 questions · 28 findings · 2 reviews

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No studies found 9 · 32.1%GRADE not reported 1 · 3.6%Very low 10 · 35.7%Low 2 · 7.1%Moderate 6 · 21.4%High 0 · 0%

Surgery vs preoperative pharmacological therapy and surgery

Health‐related quality of life · adults with growth‐hormone secreting pituitary adenomas

The review found no eligible studies for this question.

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surgery vs Pharmacological therapy

Recurrence · adults with growth‐hormone secreting pituitary adenomas

The review found no eligible studies for this question.

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surgery vs Pharmacological therapy

Adverse events · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes adverse events compared with pharmacological therapy alone (very low certainty).

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
RR 0.09 [0.01, 1.47]
1 study · 22 participants
Very low

Surgery vs Pharmacological therapy

All‐cause mortality · adults with growth‐hormone secreting pituitary adenomas

The review found no eligible studies for this question.

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surgery vs Pharmacological therapy

Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

The review found no eligible studies for this question.

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surgery vs Pharmacological therapy

Health‐related quality of life Mean AcroQoL score (0‐100) · adults with growth‐hormone secreting pituitary adenomas

Surgery alone showed no clear difference in health‐related quality of life Mean AcroQoL score (0‐100) compared with pharmacological therapy alone (low certainty).

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
MD 10
1 study · 22 participants
Low

Surgery vs preoperative pharmacological therapy and surgery

Disease‐related complications Intubation difficulties requiring postponement of surgery · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes disease‐related complications Intubation difficulties requiring… compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
RR 2 [0.19, 21.34]
1 study · 98 participants
Very low

Surgery vs preoperative pharmacological therapy and surgery

Recurrence · adults with growth‐hormone secreting pituitary adenomas

1 finding from 1 review

Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
GRADE not reported