Findings

What do systematic reviews say?

5 questions · 7 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%

Vitamin A vs no supplementation

Neonatal mortality · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in neonatal death compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.86 [0.66, 1.11]
6 studies · 1165 participants
Moderate

Vitamin A vs no supplementation

Chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in chronic lung disease (oxygen use at 28 days in survivors) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.93 [0.86, 1.01]
7 studies · 1070 participants
Moderate
Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.87 [0.77, 0.99]
5 studies · 986 participants
Moderate

Vitamin A vs no supplementation

Death or chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A probably leads to lower death or chronic lung disease (oxygen use at 28 days) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.93 [0.88, 0.99]
6 studies · 1165 participants
Moderate
Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.01]
4 studies · 1089 participants
Moderate

Vitamin A vs no supplementation

Death before 36 weeks' postmenstrual age · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in death before 36 weeks' postmenstrual age compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 1 [0.77, 1.29]
4 studies · 1089 participants
Moderate

Vitamin A vs no supplementation

Neurodevelopmental impairment at 18 to 22 months · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in neurodevelopmental impairment at 18 to 22 months compared with no supplementation (low certainty).

1 finding from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.89 [0.74, 1.08]
1 study · 538 participants
Low