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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Supervised dosing with a long‐acting medication vs unsupervised consumption

Retention [ · patients with opioid dependence

Supervised dosing with a long‐acting medication showed no clear difference in retention ‐ retention at the end of treatment (number of participants) compared with unsupervised consumption (low certainty).

2 findings from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review