Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Pain, Palliative and Supportive Care

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No studies found 3 · 60%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 0 · 0%High 1 · 20%

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Pruritus · patients with chronic kidney disease (CKD) pruritus

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1292 participants
High

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
RR 1.73 [1.2, 2.48]
5 studies · 1344 participants
Low