What do systematic reviews say?

Fecal microbiota transplantation vs control

Summary of findings table ‐ Fecal microbiota transplantation (FMT) probably leads to higher resolution of rCDI compared with control (moderate certainty).

• Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile) 2023 · Cochrane Headline outcomes only
  RR 1.92 [1.36, 2.71]
  6 studies · 320 participants
  Moderate

Fecal microbiota transplantation vs control

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in serious adverse events compared with control (moderate certainty).

• Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile) 2023 · Cochrane Headline outcomes only
  RR 0.73 [0.38, 1.41]
  6 studies · 320 participants
  Moderate

Fecal microbiota transplantation vs control

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in all‐cause mortality compared with control (low certainty).

• Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile) 2023 · Cochrane Headline outcomes only
  RR 0.57 [0.22, 1.45]
  6 studies · 320 participants
  Low

Fecal microbiota transplantation vs control

• Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile) 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported