What do systematic reviews say?

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… probably leads to lower SSI compared with mechanical bowel preparation alone (moderate certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.56 [0.42, 0.74]
  16 studies · 3917 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in surgical site infections compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.63 [0.33, 1.23]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in anastomotic leakage compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.33, 2.42]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.2 [0.01, 4.22]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 1.18 [0.77, 1.81]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… probably leads to lower anastomotic leakage compared with mechanical bowel preparation alone (moderate certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.6 [0.36, 0.99]
  10 studies · 2356 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with mechanical bowel preparation alone (moderate certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.87 [0.27, 2.82]
  3 studies · 639 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with mechanical bowel preparation alone (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.59, 1.32]
  6 studies · 2013 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 621 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

It is very uncertain whether summary of findings table ‐ Combined mechanical and oral antibiotic… changes surgical site infections compared with oral antibiotics alone (very low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.87 [0.34, 2.21]
  3 studies · 960 participants
  Very low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in anastomotic leakage compared with oral antibiotics alone (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.84 [0.21, 3.45]
  3 studies · 960 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with oral antibiotics alone (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 1.02 [0.3, 3.5]
  2 studies · 709 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with oral antibiotics alone (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 1.25 [0.68, 2.33]
  2 studies · 709 participants
  Low