Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Bacteraemia · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower bacteraemia compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.89
10 studies · 931 participants
Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 1.07
10 studies · 917 participants
Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Febrile patients and episodes · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.92
10 studies · 931 participants
Moderate