Findings

What do systematic reviews say?

11 questions · 11 findings · 1 reviews · Musculoskeletal

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No studies found 2 · 18.2%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 9.1%High 8 · 72.7%

Leflunomide vs placebo, 6 months

For outcome · patients with rheumatoid arthritis in adults

The review found no eligible studies for this question.

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Leflunomide vs placebo, 6 months

ACR 50 response at 6 months · patients with rheumatoid arthritis in adults

Summary of findings: leflunomide leads to higher ACR 50 response at 6 months compared with placebo, 6 months (high certainty).

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
RR 2.32 [1.32, 4.05]
1 study · 221 participants
High

Leflunomide vs placebo, 6 months

HAQ change from baseline Scale from: 0 to 3. · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 679 participants
High

Leflunomide vs placebo, 6 months

Pain change (0‐100 mm VAS) · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 724 participants
High

Leflunomide vs placebo, 6 months

Radiographic joint changes · patients with rheumatoid arthritis in adults

Summary of findings: leflunomide showed no clear difference in radiographic change (Change in Sharp score) compared with placebo, 6 months (high certainty).

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
RR 1.23 [0.91, 1.66]
1 study · 380 participants
High

Leflunomide vs placebo, 6 months

Withdrawals due to adverse events · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 727 participants
High

Summary of findings: leflunomide + methotrexate vs methotrexate

Change in pain (0‐100 mm VAS) · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 263 participants
High

Summary of findings: leflunomide + methotrexate vs methotrexate

Withdrawals due to adverse events · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 263 participants
Moderate

Summary of findings: leflunomide + methotrexate vs methotrexate

For outcome · patients with rheumatoid arthritis in adults

The review found no eligible studies for this question.

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: leflunomide + methotrexate vs methotrexate

ACR 50% improvement · patients with rheumatoid arthritis in adults

Summary of findings: leflunomide + methotrexate leads to higher ACR 50 at 6 months compared with methotrexate, 6 months (high certainty).

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
RR 4.35 [2.09, 9.03]
1 study · 263 participants
High

Summary of findings: leflunomide + methotrexate vs methotrexate

HAQ change from baseline Scale from: 0 to 3. · patients with rheumatoid arthritis in adults

1 finding from 1 review

Leflunomide for the treatment of rheumatoid arthritis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 263 participants
High