50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Ataxia · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher ataxia compared with placebo (moderate certainty).
1 finding from 1 review
Dizziness · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher dizziness compared with placebo (moderate certainty).
1 finding from 1 review
Fatigue · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to lower fatigue compared with placebo (moderate certainty).
1 finding from 1 review
Nausea · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher nausea compared with placebo (moderate certainty).
1 finding from 1 review
Diplopia · people with drug‐resistant focal epilepsy
Summary of findings: lamotrigine probably leads to higher diplopia compared with placebo (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine probably leads to lower time to treatment failure (any reason related to treatment)… compared with carbamazepine (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine may leads to lower time to treatment failure (any reason related to treatment)… compared with carbamazepine (low certainty).
1 finding from 1 review
Time to first seizure ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine leads to higher time to first seizure All participants Range of compared with carbamazepine (high certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine leads to higher time to first seizure Subgroup: focal onset seizures Range of compared with carbamazepine (high certainty).
1 finding from 1 review
Time to first seizure ‐ generalised epilepsy Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine showed no clear difference in time to first seizure Subgroup: generalised onset seizures Range of compared with carbamazepine (low certainty).
1 finding from 1 review
Time to 12‐month remission ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…
Summary of findings: lamotrigine showed no clear difference in time to 12‐month remission All participants Range of compared with carbamazepine (high certainty).
1 finding from 1 review