Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).
Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).
Summary of findings: lamotrigine probably leads to higher ataxia compared with placebo (moderate certainty).
Summary of findings: lamotrigine probably leads to higher dizziness compared with placebo (moderate certainty).
Summary of findings: lamotrigine probably leads to lower fatigue compared with placebo (moderate certainty).
Summary of findings: lamotrigine probably leads to higher nausea compared with placebo (moderate certainty).
Summary of findings: lamotrigine probably leads to higher diplopia compared with placebo (moderate certainty).