What do systematic reviews say?

Misoprostol vs placebo

Summary of findings: Misoprostol showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.38 [0.76, 2.51]
  1 study · 100 participants
  Low