Findings

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5 questions · 5 findings · 2 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 3 · 60%High 0 · 0%

Sulfasalazine vs Sulfasalazine and corticosteroids

Remission · patients with Induction of remission or response in Crohn's disease

Sulfasalazine probably leads to lower induction of remission compared with sulfasalazine and corticosteroids (moderate certainty).

1 finding from 1 review

Aminosalicylates for induction of remission or response in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.64 [0.47, 0.86]
1 study · 110 participants
Moderate

Sulfasalazine vs placebo

Induction of remission (CDAI <150), therapeutic response (VHI decrease >=25%) or clinical improvement · patients with Induction of remission or response in Crohn's disease

Sulfasalazine showed no clear difference in induction of remission (CDAI <150), therapeutic response (VHI… compared with placebo (low certainty).

1 finding from 1 review

Aminosalicylates for induction of remission or response in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.52 [0.95, 2.43]
3 studies · 289 participants
Low

Sulfasalazine vs placebo

Remission · patients with Induction of remission or response in Crohn's disease

Sulfasalazine showed no clear difference in induction of remission (CDAI <150) (Random Effects Model) compared with placebo (moderate certainty).

1 finding from 1 review

Aminosalicylates for induction of remission or response in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 1.38 [1, 1.89]
2 studies · 263 participants
Moderate

Sulfasalazine vs corticosteroids

CDAI <150 at 24 weeks · patients with Induction of remission or response in Crohn's disease

Sulfasalazine probably leads to lower induction of remission (CDAI <150) compared with corticosteroids (moderate certainty).

1 finding from 1 review

Aminosalicylates for induction of remission or response in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.68 [0.51, 0.91]
2 studies · 260 participants
Moderate

Methotrexate + sulfasalazine vs sulfasalazine

Maintenance of remission · Maintenance of remission in ulcerative colitis

It is very uncertain whether methotrexate + sulfasalazine changes maintenance of Remission compared with sulfasalazine (very low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in ulcerative colitis 2015 · Cochrane Headline outcomes only
RR 1.32 [0.94, 1.86]
1 study · 26 participants
Very low