Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.87]
2 studies · 122 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
OR 0.64 [0.24, 1.75]
1 study · 94 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
RR 1.11 [0.86, 1.43]
1 study · 67 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Weight gain · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Height gain (cm) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Mean standardized score on Beery VMI at 144 weeks · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 82 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
RR 2.88 [0.12, 68.88]
2 studies · 122 participants
Very low