Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

607 questions · 641 findings · 77 reviews

No studies found 114 · 17.8%GRADE not reported 25 · 3.9%Very low 170 · 26.5%Low 175 · 27.3%Moderate 123 · 19.2%High 34 · 5.3%

Systemic corticosteroids vs placebo

Pain (dichotomous) Pain improved (definitions varied)c · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in pain (dichotomous) Pain improved (definitions varied)c compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Function (dichotomous) Function improved (definitions varied)f · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids probably leads to higher function (dichotomous) Function improved (definitions varied)f compared with placebo (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Mortality or serious adverse events requiring hospital admission · people with radicular low back pain (not due to spinal stenosis)

It is very uncertain whether systemic corticosteroids changes participants who experienced a serious adverse event Adverse event… compared with placebo (very low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Participants with hyperglycemia "Transient hyperglycemia" or blood sugar increase ≥ 50 mg/dL · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in participants with hyperglycemia "Transient hyperglycemia" or blood… compared with placebo (low certainty).

1 finding from 1 review