Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 2 reviews · Heart

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 7.1%Low 5 · 35.7%Moderate 8 · 57.1%High 0 · 0%

Statins vs Control at 4 months (3 ‐ 6 months)

Combined outcome of non‐fatal myocardial infarction, non‐fatal stroke, and total number of deaths · patients with acute coronary syndrome

Statins showed no clear difference in combined outcome of non‐fatal myocardial infarction, non‐fatal… compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Statins vs Control at 4 months (3 ‐ 6 months)

Fatal & Nonfatal myocardial infarction or reinfarction · patients with acute coronary syndrome

Statins showed no clear difference in fatal and non‐fatal myocardial infarction or reinfarction compared with control at 4 months (3 to 6 months) (moderate certainty).

1 finding from 1 review

Statins vs placebo

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Aortic jet velocity (m/s) · patients with aortic valve stenosis

Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

All cardiovascular death · patients with aortic valve stenosis

Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Hospitalisation for any reason · patients with aortic valve stenosis

It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).

1 finding from 1 review

Statins vs placebo

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review