Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 8 findings · 1 reviews · Infectious Diseases

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 4 · 50%Moderate 1 · 12.5%High 1 · 12.5%

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (low certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.75 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with non‐artemisinin treatment

It is very uncertain whether single dose primaquine at 0.75 mg/kg changes participants infectious at day 5 compared with no primaquine, with non‐artemisinin partner, (very low certainty).

2 findings from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 5, by microscopy compared with no primaquine, with non‐artemisinin partner, (low certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 8, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review