Findings

What do systematic reviews say?

4 questions · 5 findings · 1 reviews · Infectious Diseases

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 60%Moderate 1 · 20%High 1 · 20%

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with severe haemolysis · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with severe haemolysis compared with no primaquine, with artemisinin partner, (low certainty).

1 finding from 1 review

Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
RR 1.54 [0.38, 6.3]
2 studies · 260 participants
Low

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
RR 0.13 [0.02, 0.94]
3 studies · 109 participants
Low
Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
RR 0.33 [0.07, 1.57]
4 studies · 246 participants
Low

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
RR 1.09 [0.93, 1.28]
3 studies · 418 participants
Moderate

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
RR 0.37 [0.29, 0.48]
5 studies · 758 participants
High